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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 5 Documents
 1 
Search results for , issue "Vol. 3, No. 3" : 5 Documents clear
Pati Pregel Pati Singkong Fosfat Sebagai Bahan Pensuspensi Sirup Kering Ampisilin Anwar, Effionora; SV, Antokalina; Harianto, Harianto
Majalah Ilmu Kefarmasian Vol. 3, No. 3
Publisher : UI Scholars Hub

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Abstract

For most reason for dry suspension is the drug changes from chemical degradation or hydrolysis like ampicillin. The dry syrups that require mixing prior to administration is solving the problem. These suspension are commersial, dry mixtures that require the addition of water at the time of dispensing. Many antibiotics are formulated as dry syrups and are intented for a pediatric patient population. There are usually fewer suspending material in suspension dry syrup than in convensional suspensions. The criteria for selecting inggredients are based both on suitable reconstitution and on physical tipe of powder mixture desired. This research was carried out the possibility of using phycical and chemical modification of cassava starch as suspending material. First, pregelatinized cassava starch was made by heated the cassava starch with added amount water. Secondly, phosphorylated by adding phosphorous oxychloride for making cross-linked reaction and adding sodium monohydrogen phosphate (Na2HPO4) for making substituted reaction respectively. Both of the cassava starch phosphate derived was used in tree formulas dry syrup, as comparative suspending material was Na Alginate. Then dry syrup was evaluated accordance to Indonesian Farmacopea ed IV included sedimentation volume, redispersion, viscosity, flowing properties, pH, and ampicillin content after seven days. The result of evaluation were particle size 355-500 µm, flow rate 2,7-4,6 g/ det. Sedimention volume at temperature 27ºC during seven days for all formulas were 0,8-1,0, and redispertion 3-5 times. The viskosity of the suspensions were 58,6-357,1 cps .Flowing properties of the liquids were plastis -plastis tixotropic, pH 4,97-5,21, and ampicillin content between 93,12-99,00%.
Perbandingan Mutu Dan Harga Tablet Amoksisilin 500 Mg Generik Dengan Non Generik Yang Beredar Di Pasaran Harianto, Harianto; W, Sabarijah; Transitawuri, Fitri
Majalah Ilmu Kefarmasian Vol. 3, No. 3
Publisher : UI Scholars Hub

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Abstract

Amoxiciilin is an antibiotic of penicillin. It has been used to treat bacterial infections that caused by Gram negative bacteria and Gram positive bacteria. Most of amoxicillin tablet has been sold with generic name and non generic name. This research was proposed to compare quality and price of amoxicillin tablet 500 mg at the drug store. Especially, for amoxicillin tablet 500 mg generic and non generic. Determination of quality amoxicillin tablet could be showed from standard quality of amoxicillin tablet was based at USP XXVI. Identification, dissolution and assay were included standard quality of amoxicillin tablet. Identification test was performed by TLC with mobile phase consist of methanol, chloroform, water and pyridine (90:80:30:10). Assay of dissolution test was performed by HPLC with mobile phase potassium dihydrogen phosphate buffer and acetonitrile (39:1). Assay of tablet was performed by HPLC with mobile phase potassium dihydrogen phosphate buffer and acetonitrile (96:4). The experiment was held to 15 brands of tablet which they had consisted 3 brands of generic tablet and 12 brands of non generic tablet. The test resulted that every brands of tablet fulfilled standard quality of amoxicillin tablet. But in the test, there was variation of price, in ordinarily price of non generic tablet was more expensive than generic tablet.
Uji Hambatan Tumorigenesis Sari Buah Merah (Pandanus Conoideus LAM.) Terhadap Tikus Putih Betina Yang Diinduksi 7,12 Dimetilbenz(a)Antrasen (DMBA) Mun‘im, Abdul; Andrajati, Retnosari; Susilowati, Heni
Majalah Ilmu Kefarmasian Vol. 3, No. 3
Publisher : UI Scholars Hub

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Abstract

Red fruit (Pandanus conoideous Lam.) has been known by public as a medicine for any kind of diseases, among of them is for cancer. To determine the carcinogenesis inhibition effect of red fruit extract , we have examined the effect on 7,12- dimethylbenz[a]anthrasene (DMBA)-induced rat lungs cancer model in female Sprague-Dawley rats. The extract was tested at 0.21 ml/200 g bw; 0.43 ml/200 g bw and 0.88 ml/ 200 g bw. The experiment was terminated at day 120. Lung histology was used to evaluate carcinogenesis inhibition. The result showed that the extract at 0.21 ml/200g bw improved lung carcinogenesis inhibition than other dose.
Pengaruh Cara Pengeringan Simplisia Daun Senggani (Melastoma malabathricum L.) Terhadap Aktivitas Antioksidan Menggunakan Metode DPPH (2,2-difenil-1-pikrilhidrazil) Luliana, Sri; Purwanti, Nera Umilia; Manihuruk, Kris Natalia
Pharmaceutical Sciences and Research Vol. 3, No. 3
Publisher : UI Scholars Hub

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Abstract

Drying is the most important step to keep the compound stability in simplicia. The objective of this research is to know the effect of drying methods on antioxidant activity in Melastoma malabathricum L. The drying methods tested were oven-drying at 40°C, direct sunlight, indirect sunlight, air-drying at ± 25°C and fresh samples as control. Result revealed that the drying methods of simplicia were significant differences for antioxidant activity in Melastoma malabathricum L. (p < 0,05). Drying method that has the highest antioxidant activity was by air-drying at ± 25°C is 54.60 %.
Perbandingan Efek Larvasida Minyak Atsiri Daun Cengkeh (Syzygium aromaticum L.) Varietas Zanzibar dengan Temephos terhadap Larva Nyamuk Aedes aegypti Pamungkas, Ridzmullah Wishnu; Syafei, Neneng Syarifah; Soeroto, Arto Yuwono
Pharmaceutical Sciences and Research Vol. 3, No. 3
Publisher : UI Scholars Hub

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Abstract

The use of temephos as larvicides in disease prevention Dengue Hemorrhagic Fever (DHF) in Indonesia has been going on for 40 years. Larviciding very long led the resistance to temephos. Cloves, one of native Indonesia plant contains eugenol that are toxic to the insect’s body. This study aims to examine the effectiveness of Zanzibar clove leaf essential oil compared to temephos in killing the larvae of Aedes aegypti. This study uses experimental laboratory research design. The samples are larvae of Aedes aegypti stage III. The mosquito larvae were classified into six groups, each given a clove leaf essential oil with different concentrations. Next will be observed the number of larvae that die after 24 hours. Based on statistical test p-value p < 0.05 it indicates there are differences in the average mortality in the test group, and post hoc analysis showed the test group with 100 ppm of essential oil is not a significant difference with temephos. This study suggests the essential oil of clove leaf varieties of Zanzibar has the same effectiveness with temephos in killing the larvae of Aedes aegypti.

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